AE1/AE3 recognizes the acidic and basic
(Type I and II) subfamilies of cytokeratins. The combination of these two
antibodies can be used to detect most human epithelia. The acidic cytokeratins
have molecular weights of 56.5, 55, 51, 50, 50, 48 46, 45, and 40 kDa. The basic
cytokeratins have molecular weights of 65-67, 64, 59, 58, 56 and 52 kDa. This
pan cytokeratin antibody has proved useful as a screener for the majority of
human carcinomas.